Are you in need of the most current information about multiple myeloma. Learn more about the symptoms, causes, diagnosis, risk factors, and treatment of multiple myeloma. Multiple myeloma dr harpreet singh bhatia dmch, ludhiana,punjab 2. A multiple myeloma diagnosis can be overwhelming, making you feel sad, scared, or anxious. Ketika anda mengalami multiple myeloma, sel plasma akan memproduksi protein secara berlebihan yang pada akhirnya bisa merusak beberapa organ tubuh seperti tulang dan ginjal. Myeloma canada po box 326 kirkland, qc h9h 0a4 telephone.
Kasus penyakit multiple myeloma kasus multiple myeloma menempati 200, dianggap sebagai keganasan kedua yang paling umum dari darah. Persentase risiko seseorang menderita penyakit ini adalah 0,76%, dengan perkiraan angka kejadian sebanyak 1 dari 2 orang. Some people with multiple myeloma, especially those with early stages of the condition, have no concerning signs or symptoms. Multiple myeloma is cancer that starts in the bone marrows plasma cells. Xrays and sometimes other imaging scans are used to check for signs of myeloma in your bones. Myeloma often damages the bone and is usually called multiple myeloma because most people have multiple bone lesions.
The immune system is made up of several types of cells that work together to fight infections. Sel plasma adalah salah satu jenis sel darah putih yang berfungsi untuk membentuk antibodi. Multiple myeloma mm is a cancer that occurs in plasma cells, which fall under the category of white blood cells that are in charge of antibody production. Pdf advances in the imaging and treatment of multiple myeloma have occurred over.
Multiple myeloma accounts for approximately 10% of hematologic malignancies. If patients or their loved one have been diagnosed with multiple myeloma, myeloma. Herman liu feb 2010 discussion 1 basics 2 work up 3 treatment discussion 1 basics 2 work up 3 treatment terminology 1. This article summarises the current status and highlights how an understanding of both is necessary. Most people with myeloma are diagnosed after age 65. Myeloma begins when healthy plasma cells in the bone. In the last decade, therapy and diagnosis of multiple myeloma have seen more changes. Free download myeloma powerpoint presentation slides.
Multiple myeloma, the most common bone malignancy, is occurring with increasing frequency in older persons. Kinomewide rnai studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoidrestricted kinase, grk6 rodger e. Unlike multiple myeloma, solitary plasmacytoma is only one tumor, usually in a bone. Myeloma begins when healthy plasma cells in the bone marrow change and grow out of control. Multiple myeloma is a cancer of certain cells of the bone marrow called plasma cells. Pdf multiple myeloma is characterised by the proliferation of malignant plasma cells. Multiple myeloma accounts for around 1% of all cancers worldwide and 1015% of all hematological neoplasms. Multiple myeloma mm, the second most common blood cancer in adults, is a clonal plasma. Median survival is about three years, but some patients have a life expectancy of 10 years. What is multiple myeloma definition, answers and support. Penderita multiple myeloma rentan mengalami infeksi pernapasan dan infeksi saluran kemih, penanganan yang terlambat dapat mengakibatkan kematian. New triplet therapy in multiple myeloma medscape jun.
Treatment of multiple myeloma with highrisk cytogenetics. Had my second transplant in january 2011 and had a good 3 12 year remission. Plasma cells make antibodies against infectious agents such as viruses and. Some people with multiple myeloma, especially those with. Myeloma is usually called multiple myeloma because most people 90% or more have multiple bone lesions when diagnosed or lesions develop over the course of the illness. As the only national organization exclusively devoted to the canadian myeloma community. If patients or their loved one have been diagnosed with multiple. Many core booklets and key medical articles are translated as well.
Solitary plasmacytoma is a mass of myeloma cells that involves only 1 site in the bone or, less commonly, other organs, such as in the upper respiratory tract, including the. Kaplanmeier estimates of progression free survival and overall survival benboubker l et al. Com multiple myeloma adalah termasuk kanker ganas yang berasal dari sel plasma, yakni sejenis sel darah putih yang diproduksi di sumsum tulang yang membantu tubuh melawan infeksi. Kondisi ini terjadi saat selsel plasma yang tidak normal abnormal. Multiple myeloma mm, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. Abstract multiple myeloma accounts for approximately 10% of hematologic. Understanding the key aspects of a multiple myeloma diagnosis. The serum free light chain ratio can be used to further define the risk of progression for those. Normal plasma cells are an important part of the bodys immune system.
Plasma cells are a type of white blood cell found in bone marrow, which is the soft tissue inside most of your bones that produces. Born in 1962, i was diagnosed with stage iii multiple myeloma igg lambda in june 2003, had my first bone marrow or stem cell transplant on july 18 2005 and stayed in complete remission for 4 12. Multiple myeloma early detection, diagnosis, and staging. Vincent rajkumar multiple myeloma accounts for approximately 10% of hematologic malignancies. Multiple myeloma is a disease in which a neoplastic proliferation of plasma cells produces a monoclonal immunoglobulin. From basic information about cancer and its causes to indepth information on specific cancer types including risk factors, early detection, diagnosis, and treatment options youll find it here. Amyloidosis should be suspected in the presence of. Read a 1page fact sheet that offers an introduction to multiple myeloma. Plasma cells make antibodies against infectious agents such as viruses and bacteria. In germany there are around 6500 new cases of multiple myeloma each year and it is the third most commonly occurring disease of the blood after leukemia and nonhodgkin lymphoma. Cleveland clinic taussig cancer institutes multiple. Myeloma nz is a new foundation in nz to provide a deeper level of support for those who affected by multiple myeloma. Kanker ini umumnya ditandai dengan nyeri pada tulang.
Multiple myeloma is a disease of the elderly 70yearold male is the typical patient. Ppt multiple myeloma powerpoint presentation free to. It may present with myriad complications including anaemia, hypercalcaemia, renal failure, recurrent infections or bony lytic. The risk of multiple myeloma is highest among african americans and lowest among asian americans. Whether you or someone you love has cancer, knowing what to expect can help you cope. Growing older increases the chance of developing multiple myeloma.
Bisphosphonates should be prescribed for all patients with symptomatic multiple myeloma. Multiple myeloma is a form of cancer that occurs due to abnormal and uncontrolled growth of plasma cells in the bone marrow. Pada awalnya, multiple myeloma tidak menimbulkan gejala apapun. Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. Myeloma is usually diagnosed when blood and urine tests find paraprotein, and bone marrow tests show an increased number of plasma cells. Because patients with solitary plasmacytomas have a higher risk for multiple myeloma, they must be monitored closely with regular checkups.
Criteria for the classification monoclonal gammopathies, multiple myeloma and related disorders. Multiple myeloma is a cancer which affects cells which are growing in the bone marrow. Join today to find the additional information and resources you need to make an informed decision. There are also a great number of reputable organizations that provide trusted information on multiple myeloma and related issues see sidebar.
Multiple myeloma merupakan salah satu jenis kanker darah. Multiple myeloma is the second most common type of blood cancer after leukemia. Multiple myeloma early detection, diagnosis, and staging cancer. Visit our online multiple myeloma forum to research helpful cancer topics and obtain valuable feedback and support. The test results help your doctor work out the type of myeloma you have and the best treatment plan for you. Xrays and sometimes other imaging scans are used to check. Multiple myeloma is a type of cancer that affects plasma cells. It represents approximately 1% of all cancers and 2% of all cancer deaths. Expect to see more functional mris in nz medical practice. Multiple myeloma terjadi saat sel plasma abnormal myeloma di sumsum tulang tumbuh dan berkembang dengan sangat cepat, serta merusak selsel sehat, seperti sel darah merah, sel darah putih, dan keping darah, yang ada di sekitarnya.
Multiple myeloma mm, also known as symptomatic plasma cell myeloma, is a plasma cell malignancy. Dec 29, 2017 written by a researcher and a physician with over 20 years of experience treating patients with myeloma, understanding multiple myeloma provides a comprehensive overview of symptoms, diagnosis, treatment options, supportive care, and much more. Plasma cells are a type of white blood cell that help the body fight infections by producing proteins called antibodies. Multiple myeloma is a cancer of the bone marrow plasma cells. Myeloma is usually a slowgrowing cancer, and for this reason, the outlook depends on factors such the age of the person diagnosed, the aggressiveness of the cancer and the development of complications. It is almost invariably preceded by premalignant stages of monoclonal gammopathy of undetermined significance mgus and smoldering mm smm, although not all cases of mgus will eventually progress to mm. First described in 1848, mm is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein m protein. Although the peak age of onset of multiple myeloma is 65 to 70 years of age, recent statistics indicate both increasing incidence and earlier age of onset. Kanker jenis ini lebih banyak terjadi pada pasien berjenis kelamin lakilaki dibanding dengan perempuan. Different types of multiple myeloma the myeloma crowd. The diagnosis requires 10% clonal bone marrow plasma cells or a biopsy proven plasmacytoma plus evidence of one or more multiple. As a patient, becoming informed about the nature and treatment of this disease can help facilitate a more active and supportive relationship with your healthcare team. Bone marrow is the spongy tissue inside bones where all blood cells grow and mature.
Multiple myeloma 2016 boca raton regional hospital. Multiple myeloma gejala, penyebab dan mengobati alodokter. Namun, sebanyak 90% kasus myeloma tergolong dalam jenis multiple myeloma. Multiple myeloma is currently still an incurable disease, but during the past. Myeloma associated al amyloidosis is reported in 1230% of multiple myeloma patients.
Patients may present with bone pain or with symptoms that are often nonspecific, such as nausea. Multiple myeloma is a type of cancer formed by cancerous plasma cells in the blood. Powerpoint is the worlds most popular presentation software which can let you create professional myeloma powerpoint presentation easily and in no time. A multiple myeloma expert helps newly diagnosed patients understand the standard of care for their disease. Multiple myeloma a new era of treatment strategies volume 1. As it progresses, bone pain, bleeding, frequent infections, and anemia may occur. Hal ini terjadi pada orang tua, 5065tahun adalah tingginya insiden usia, usia onset dalam beberapa tahun terakhir di muka. Multiple myeloma mm is an aggressive malignant neoplasm of plasma cells that accumulates in the bone.
Individual counseling, facetoface and online support groups, and patienttopatient networks are available to help you cope emotionally. Multiple myeloma genetic and rare diseases information. The imfs patient handbook is designed to help you to understand multiple myeloma which we refer to simply as myeloma. Symptoms and signs include anemia, skin lesions, weakness, and bone fractures. It is characterised by a clonal population of bone marrow plasma cells which secrete a monoclonal paraprotein or an immunoglobulin free light chain flc figure 1a, b. This type of myeloma responds well to treatment, usually radiation andor surgery. A free powerpoint ppt presentation displayed as a flash slide show on id. All are available free of charge online and in printed copy by mail. For more publications this is only one of many free booklets for people. A new combination, with the recently approved oral agent ixazomib ninlaro, can. The international myeloma foundation can provide further support for myeloma patients. These patients typically fulfill the diagnostic criteria for multiple myeloma and have evidence of amyloid light chain deposition confirmed by congo red staining.
Multiple myeloma adalah kanker yang menyerang sel plasma di sumsum tulang. Some early cancers may have signs and symptoms that can be noticed, but that is not always the case. Myeloma is called multiple because there are frequently multiple. Multiple myeloma mm is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance mgus to plasma cell leukemia.
Cleveland clinic taussig cancer institutes multiple myeloma program our mission the primary mission is to provide patients and physicians access to innovative treatment options, medical expertise, and. Cancer articles and journals intl myeloma foundation. From basic information about cancer and its causes to indepth information on specific cancer types including. Learn about imfs library of cancer articles, journals, and other publications for patients, caregivers, and healthcare professionals. In germany there are around 6500 new cases of multiple myeloma each. Progression free survival at 12 months was 91% for the entire cohort. Because the vertebrae are often affected by myeloma, and.
Born in 1962, i was diagnosed with stage iii multiple myeloma igg lambda in june 2003, had my first bone marrow or stem cell transplant on july 18 2005 and stayed in complete remission for 4 12 years. A cancerous or malignant plasma cell is called a myeloma cell. The libraries at cancer centers also stock uptodate. Triplet therapy is the initial preferred treatment for myeloma, and various combinations are used around the world. It is synonymous with myeloma and plasma cell myeloma. Myeloma is called multiple because it frequently involves multiple areas in the body. Multiple myeloma mm, also known as plasma cell myeloma and simple myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies.
Myeloma is a cancer of the plasma cells in the bone marrow, the spongy tissue inside of bones. Berikut ini adalah gejala multiple myeloma lainnya yang bisa anda kenali, di antaranya. National cancer institute what you need to know about tm multiple myeloma u. This fact sheet is available as a pdf, so it is easy to print out.
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